| Pair Name | Gossypol, Gemcitabine | ||
| Phytochemical Name | Gossypol (PubChem CID: 3503 ) | ||
| Anticancer drug Name | Gemcitabine (PubChem CID: 60750 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gossypol, Gemcitabine | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Expression | MCL1 | hsa4170 | |
| Up-regulation | Expression | PMAIP1 | hsa5366 | |
| In Vitro Model | CNE-1 | Nasopharyngeal carcinoma | Homo sapiens (Human) | CVCL_6888 |
| YCC-16 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_9649 | |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| Result | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. PLoS One. 2012;7(12):e50786. doi: 10.1371/journal.pone.0050786. | Click |
